Pediatric Dermatology: Diagnostic Challenges. Part 1

Isotretinoin is approved for severe, recalcitrant nodular acne
that has proved unresponsive to conventional therapies, including
systemic antibiotics.
Alan R.
Shalita, MD, Commonwealth Educational institution of New York Wellbeing
Sciences Nub, Brooklyn, NY, suggests that these guidelines be expanded
to include severe, refractory acne that is mentally or physically
scarring.

Typical dosing guidelines for isotretinoin are:

Full dose: 0.5-2 mg/kg per day for 15-20 weeks

Initial dose should be no more than 0.5 mg/kg per day

Only
rarely is a dose of 2 mg/kg per day required.
In indefinite quantity, doses of 0.1-0.5 mg/kg per day are also
effective in clarification severe acne.
However, in a ideal 20-week layer, when these doses were compared with
1 mg/kg per day, it was found that recurrence was twice as frequent
when the lower doses were employed.
Therefore, in a touchstone 20-week path, the 1 mg/kg per day dose is
preferred.

In Europe, the daily dose is idea to be less important than the sum dose.
As long as a unit dose of 120-150 mg/kg was reached, recurrence was not greater with the lower daily doses.
Of track, the idiom bed must be longer to achieve the appropriate final exam totality doses if lower daily doses are used.
This could mean greater risk of pregnancy in women of child-bearing potential drop.

This is a part of article Pediatric Dermatology: Diagnostic Challenges. Part 1 Taken from "Acne Isotretinoin Accutane" Information Blog